Tailoring Adipose Stem Cell Trophic Factor Production with Differentiation Medium Components to Regenerate Chondral Defects
نویسندگان
چکیده
منابع مشابه
Mesenchymal stem cell enhances chondral defects healing in horses
The purpose of this study was to evaluate the effect of intralesional Mesenchymal Stem Cells (MSC) on the treatment of experimentally induced articular chondral defects in horses, emphasizing the benefits of this application in veterinary medicine. Chondral defects were induced in the medial femoral trochlea of both hind limbs of four horses. Thirty days post induction; the horses were divided ...
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Objective(s) Bone marrow is the traditional source of human multipotent mesenchymal stem cells (MSCs), but adipose tissue appears to be an alternative and more readily available source. In this study, rat adipose-derived stem cells (ADSCs) were induced to differentiate into Schwann-like cells and compared with rat bone marrow stem cells (BMSCs) for their Schwann-like cells differentiation pote...
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Background: Adipose-derived stem cells (ADSC) could be an appealing alternative to bone marrow stem cells (BMSC) for engineering cell-based osteoinductive grafts. Meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. Therefore, we assayed and compared the melatonin effect on osteogenic differentiation of BMSC with that of ADSC. Methods: Mesenchymal...
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Background: The cultured mesenchymal stem cells (MSC) have been used in many clinical trials however, there are still some concerns about the cultural conditions. One concern is related to the use of FBS as a widely used xenogeneic supplement in the culture system. Human platelet-rich plasma (hPRP) is a candidate replacement for FBS. In this study, the effect of hPRP on MSC proliferation and os...
متن کاملChondrogenic Differentiation of Adipose-derived Stem Cells with Adenovirus Mediated Growth and Differentiation Factor 5
Introduction: Adipose-derived stem cells (ADSCs) have shown the potentials to differentiate toward the chondrogenic phenotypes with growth factors [1]. But the chondrogenic differentiation with proteomic growth factor needs a prolonged duration of in vitro culture, which would obviously delay the treatments to patients. Growth and differentiation factor 5 (GDF5) is a member of the TGF-beta supe...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2013
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2012.0233